If I stay in a very cheap hotel with minimal security I take extra care to ensure that valuables are placed in the room-safe and that the door is locked securely
I have always assumed that when I close the door in one of the international chains such as Radisson, Grand Hyatt, Sheraton, Waldorf Astoria, Fairmont, Park Plaza, that their door key system is 100% secure but researchers have discovered that some door lock technology is vulnerable to being hacked.
Best to use that room safe deposit box every time!